Unveiling Water-Guided
Refinement
Beyond 3D prediction: achieving biological reality. We specialize in ultra-precision refinement for Proteins, RNA, DNA, and Mega-complexes through computational excellence.
[ IN DEVELOPMENT: HANFOLD ]
Scientific Authority
Water-Guided Refinement (WGR)
True biological function happens in aqueous environments. Our WGR technology integrates explicit water molecules and thermodynamic constraints to resolve atomic clashes and backbone strain, transforming “dry” models into physiologically valid structures.
HanjariFold-Endgame
The ultimate refinement solution for complex biological systems.
- ✔Hetero-Complexes: Protein + RNA + DNA Hybrids
- ✔Scalability: Optimized for Mega-Complexes (Ribosomes, etc.)
- ✔Validation: Global standard MolProbity & Rama-Z optimization
HanFold (TBA)
Integrating AI-based de novo prediction with physics-based refinement.
- •End-to-End: Sequence to Refined Structure
- •Computational chemistry & AI fusion architecture
- •Aimed for groundbreaking accuracy in CASP-level challenges
⚡ Validation & Global Standards
“We prove our performance through evidence-based results. ProteinMaker™ actively participates in world-renowned protein structure prediction and refinement competitions to validate our HanFold and HanjariFold pipelines against the highest global benchmarks.”
MolProbity 1.94 Achieved
Clashscore 2.74 Achieved