Water-Guided
Refinement
ProteinMaker™ introduces the HanjariFold-Endgame engine. We transform low-resolution experimental data and AI-predicted models into publication-grade atomic masterpieces.
Proof of Concept
Conquering the Mega-Complex
We refined the 70S Ribosome (PDB: 4V9C)—a 340,000-atom behemoth. Using 3.3Å low-resolution data, our engine restored the structural integrity to a level previously thought impossible for complexes of this scale.
Explicitly placed and optimized hydration shell, resolving strain and restoring biological reality in under 60 minutes.
Refinement Specializations
Experimental Model Repair
Turn weak 3.5Å+ Cryo-EM/X-ray density maps into high-fidelity structures. We solve side-chain ambiguity through physics-based inference.
AI-Model Validation
Post-AlphaFold3/Boltz optimization. We eliminate atomic clashes and enforce stereochemical integrity for reliable In-Silico screening.
Aqua-Polish Hydration
Restoration of the hydrogen-bond network. Essential for drug-binding analysis and molecular dynamics (MD) simulations.
“We don’t just predict;
We discover the biological truth.”
Low-resolution maps are like foggy windows. ProteinMaker’s Aqua Polish technology doesn’t create what’s not there; it uses thermodynamic constraints to wipe away the noise and reveal the underlying structural integrity that nature intended.